反应详情

A mixture of 2-thiocytosine (0.88 g.), sodium hydroxide (0.32 g.), water (5 ml.) and 3-chloropropanol (0.8 g.) was heated at 90° for 1 hour and then cooled. The mixture was extracted with EtOAc and the extract dried and then evaporated to dryness to give 4-amino-2-(3-hydroxypropylthio)pyrimidine (1.5 g.) which was used without further purification.

1. temperaturewas heated at 90° for 1 hour
2. temperaturecooled
3. extractionThe mixture was extracted with EtOAc
4. customthe extract dried
5. customevaporated to dryness