HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-Chloropyrazine → 2-Chloro-6-(3-[2,2,2-trifluoroethyl]thioureido)pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-Chloropyrazine | HCID 118458 | — |
| Reactant | 1,1,1-Trifluoro-2-isothiocyanatoethane | HCID 13883777 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloro-6-(3-[2,2,2-trifluoroethyl]thioureido)pyrazine | HCID 54483419 | — |
Reaction Steps
2,2,2-Trifluoroethylisothiocyanate (6 ml.) was added to 2-amino-6-chloropyrazine (6 g.) in acetonitrile (50 ml.) and the mixture heated under reflux on the steam bath for 6 hours. On cooling the precipitated solid was recrystallised from toluene to give 2-chloro-6-(3-[2,2,2-trifluoroethyl]thioureido)pyrazine, m.p. 170°-172°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04451463 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-ef5b275e22484a1295d2fff26fe41d53 |
| Source note | uspto-grants-1984_05 |