Ammonia → 2-(2,2,2-Trifluoroethyl)guanidino-6-chloropyrazine

Participants

Reaction Steps

To a solution of 2-chloro-6-(3-[2,2,2-trifluoroethyl]thioureido)pyrazine (0.7 g.) in alcoholic ammonia (35 ml.) was added yellow mercuric oxide (0.65 g.) and the mixture stirred overnight at room temperature. The mixture was filtered and the filtrate evaporated. The residue was recrystallised from toluene/petroleum ether (b.p. 60°-80°) to give 2-chloro-6-(2-[2,2,2-trifluoroethyl]guanidino)pyrazine (0.5 g.), m.p. 139°-140°.

Provenance & Evidence