4-Chlorobenzoyl chloride → HCID 14368005, compound

HRID 544590Notes

Reaction equation

HRID 544590 reaction equation
[CH2:1]([N:5]1[CH2:12][CH:11]2[CH:13]([OH:14])[CH:7]([CH2:8][N:9]([CH2:15][CH2:16][CH2:17][CH3:18])[CH2:10]2)[CH2:6]1)[CH2:2][CH2:3][CH3:4].[Cl:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[CH2:15]([N:9]1[CH2:10][CH:11]2[CH:13]([O:14][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][C:20]([Cl:19])=[CH:21][CH:22]=3)[CH:7]([CH2:6][N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:12]2)[CH2:8]1)[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 20458405HCID 20458405, compound

Product 1

HCID 14368005HCID 14368005, compoundYield 57.5%

Procedure

10.18 g of 3,7-di-n-butyl-3,7-diazabicyclo[3.3.1]nonane-9-ol are reacted with 7.7 g of 4-chloro-benzoyl chloride as described in Example 8 to obtain 3,7-di-n-butyl-9-(4'-chlorobenzoyloxy)-3,7-diazabicyclo[3.3.1]nonane, which is converted into its fumarate. The salt, melting at 180°-181° C., is obtained with a yield of 57.5%.

Sources & evidence

ORD record
ord-ed1cb038dc944dffabdb14041a5c72a0
Source dataset
uspto-grants-1984_05
Patent number
US04451473

Reaction notes

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