3,5-Dimethylisoxazole → HCID 5271192, compound

HRID 544604Notes

Reaction equation

HRID 544604 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[O:4][N:3]=1.[C:8]([O:12][C:13]([C:15]1[CH:28]=[CH:27][C:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]Br)=[CH:17][CH:16]=1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>>[C:8]([O:12][C:13]([C:15]1[CH:28]=[CH:27][C:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:7][C:5]2[O:4][N:3]=[C:2]([CH3:1])[CH:6]=2)=[CH:17][CH:16]=1)=[O:14])([CH3:10])([CH3:9])[CH3:11]

Participants

3

Reactant 2

HCID 93123,5-DimethylisoxazoleHCID 13450888HCID 13450888, compound

Product 1

HCID 5271192HCID 5271192, compoundYield 23%

Procedure

[I; R is CH3, n is 5, X is O, Ar is 4--(CH3)3 --COOCC6H4 ], m.p. 76° C., in 23% yield from 3,5-dimethylisoxazole and 6-(4-tertiary-butyloxycarbonylphenoxy)hexyl bromide; MIC vs. rhinovirus Type 2 in vitro=6.2 μg/ml.

Sources & evidence

ORD record
ord-e83b7ef407964329b9fccd4e6daf33ed
Source dataset
uspto-grants-1984_05
Patent number
US04451476

Reaction notes

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