Dimethylamine → HCID 5271199, compound

Participants

Reaction Steps

A solution of 8.0 g of 5-[7-(4-chlorocarbonylphenoxy)heptyl]-3-methylisoxazole in 50 ml of dry toluene was saturated with dimethylamine gas over a 30 minute period. The reaction mixture was concentrated in vacuo, and the residue was dissolved in ether. The ether solution was boiled, treated with petroleum ether until turbid and cooled to produce 6.0 g of N,N-dimethyl-4-[7-(3-methyl-5-isoxazolyl)heptyloxy]benzamide, m.p. 58°-59° C.; MIC vs. polio-2 virus in vitro=2.5 μg/ml.

Provenance & Evidence