Hydroxyamine hydrochloride → HCID 86107496, compound

Participants

Reaction Steps

To a solution of 1.6 g of 5-[7-(4-propionylphenoxy)heptyl]-3-methylisoxazole (Example 32) in 40 ml of ethanol was added a solution of 368 mg of hydroxylamine hydrochloride and 730 mg of sodium acetate in 8 ml of water. The reaction mixture was heated at reflux overnight and then concentrated in vacuo. The residue was recrystallized from aqueous ethanol to give 1.0 g of 5-[7-(4-propionylphenoxy)heptyl]-3-methylisoxazole oxime, colorless solid, m.p. 88°-89° C.; MIC vs. rhinovirus Type 2 in vitro=2.6 μg/ml; and vs. polio-2 virus at 0.2 μg/ml.

Provenance & Evidence