反应详情

0.10 g of 2-[4,5-bis-(p-methoxyphenyl)-thiazol-2-ylthio]-acetaldehyde is dissolved in 3 ml of methanol, 0.01 g of sodium borohydride is added and the mixture is stirred for 15 minutes. It is then concentrated to dryness by evaporation under reduced pressure and digested with 20 ml of ice-water. After some time crystallisation occurs. After 2 hours the crystals are filtered with suction, washed with water and sucked dry. 2-[2-hydroxyethylthio]-4,5-bis-(p-methoxyphenyl)-thiazole having a melting point of 82°-83° is obtained.

1. concentrationIt is then concentrated to dryness by evaporation under reduced pressure
2. customAfter some time crystallisation
3. filtrationAfter 2 hours the crystals are filtered with suction
4. washwashed with water
5. customsucked dry