反应详情

1.2 g of 2-(2-bromoethylthio)-4,5-bis-(p-methoxyphenyl)-thiazole are dissolved in 10 ml of polyethylene glycol, 0.5 ml of water and 0.5 g of potassium hydroxide are added, the mixture is heated at 120° for 30 minutes, cooled to room temperature, diluted with 50 ml of water and left to stand at +5° for 2 hours. The precipitated crystals are filtered off and recrystallised from diethyl ether/hexane. 2-(2-Hydroxyethylthio)-4,5-bis-(p-methoxyphenyl)-thiazole having a melting point of 82°-83° is obtained.

1. temperaturethe mixture is heated at 120° for 30 minutes
2. waitleft
3. filtrationThe precipitated crystals are filtered off
4. customrecrystallised from diethyl ether/hexane