反应详情

A suspension of 1,1-dimethylethyl[[3-[1-(phenylmethyl) -3-pyrrolidinyl]phenyl]methyl]carbamate (4.50 g, 12.3 mmol) and 20% palladium on charcoal catalyst (0.30 g) in methanol (100 mL) was hydrogenated in a Parr apparatus at 3 atm. The suspension was filtered through a pad of Celite and the filtrate concentrated to give an orange oil. This oil was chromatographed (silica gel, dichloromethane-methanol 1:1 containing 1% ammonia) to give the title compound (2.99 g, 88%) as a pale yellow oil.

1. filtrationThe suspension was filtered through a pad of Celite
2. concentrationthe filtrate concentrated
3. customto give an orange oil
4. customThis oil was chromatographed (silica gel, dichloromethane-methanol 1:1 containing 1% ammonia)