3-(4-Azidophenyl)prop-2-enoyl chloride → HCID 86739435, compound

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Reaction Steps

Subsequently, 8.5 g (40 millimoles) of the p-azidocinnamic acid chloride was dissolved in chloroform, and 4.8 g (40 millimoles) of N,N-diethylaminoethylenediamine was added thereto at a reaction temperature of 10° to 20° C., after which the resulting solution was further allowed to react for 1 hour. The chloroform was distilled off under reduced pressure, and 100 ml of water was added to the resulting oily substance, after which a solution of 1.7 g of sodium hydroxide in 20 ml of water was added thereto on an ice bath. The organic layer separated was extracted with chloroform, and the extract was further washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain 11 g of an oily substance as the distillation residue. This oily substance decomposed at 130° C. with formation of bubbles and generation of heat. This oily substance was identified as the compound of this invention by analysis using the following spectral means: ##STR115##

Provenance & Evidence