HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 20458174, compound → HCID 13576946, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 20458174 | HCID 20458174 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 13576946 | HCID 13576946 | — |
Reaction Steps
8.99 g of 2-(5-chloro-2-methoxy-4-morpholinophenyl)-propionic acid (0.03 mole) are boiled in 48% hydrogen bromide solution for 2 hours. The reaction mixture is cooled and concentrated and extracted 3 times with methylene chloride. The organic phases are washed neutral, combined, dried over sodium sulphate and concentrated in a vacuum rotary evaporator. In this manner 5-chloro-3-methyl-6-(morpholin-4-yl)-benzofuran-2(3H)-one having a melting point of 103°-105° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04451462 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-a82888113baa42d8900b63a9705a2f29 |
| Source note | uspto-grants-1984_05 |