2-(3-Pyrrolidinyl)benzenemethanamine → HCID 15288429, compound

HRID 54473Notes

Reaction equation

HRID 54473 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:17])=[C:11](F)[C:12]=3[O:14][CH3:15])[C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5]2)[CH2:3][CH2:2]1.FBF.[NH:25]1[CH2:29][CH2:28][CH:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[CH2:36][NH2:37])[CH2:26]1>>[NH2:37][CH2:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[CH:27]1[CH2:28][CH2:29][N:25]([C:11]2[C:12]([O:14][CH3:15])=[C:13]3[C:8]([C:7](=[O:18])[C:6]([C:19]([OH:21])=[O:20])=[CH:5][N:4]3[CH:1]3[CH2:3][CH2:2]3)=[CH:9][C:10]=2[F:17])[CH2:26]1

Participants

3

Reactant 2

HCID 152884282-(3-Pyrrolidinyl)benzenemethanamineHCID 178493651HCID 178493651, compound

Product 1

HCID 15288429HCID 15288429, compound

Procedure

Starting from difluoroborane 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline -carboxylate (1.13 g, 3.3 mmol) and 2-(3-pyrrolidinyl) benzenemethanamine, a procedure analogous to that given in Example 1, provided the fluoroborate ester of the title compound.

Sources & evidence

ORD record
ord-ac7db58cd27a41fb882dc442313df8fa
Source dataset
uspto-grants-1997_04
Patent number
US05622966

Reaction notes

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