HCID 13576910, compound → HCID 20458178, compound

HRID 544732Notes

Reaction equation

HRID 544732 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[C:19]([CH3:20])=[CH:18][C:12]2[CH:13]([CH3:17])[C:14](=[O:16])[O:15][C:11]=2[CH:10]=1)C1C=CC=CC=1.[H][H]>O1CCOCC1.[Pd]>[NH2:8][C:9]1[C:19]([CH3:20])=[CH:18][C:12]2[CH:13]([CH3:17])[C:14](=[O:16])[O:15][C:11]=2[CH:10]=1

Participants

5

Reactant 2

HCID 13576910HCID 13576910, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20458178HCID 20458178, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

4 g of 6-dibenzylamino-3,5-dimethylbenzofuran-2(3H)-one are dissolved in 40 ml of dioxane and reduction is carried out at room temperature, under normal pressure, with hydrogen and with 0.4 g of palladium-on-carbon. The mixture is then filtered, and the filtrate is concentrated to dryness by evaporation and recrystallised from methanol. In this manner 6-amino-3,5-dimethylbenzofuran-2(3H)-one having a melting point of 123°-124° C. is obtained.

Workup

  1. filtrationThe mixture is then filtered
  2. concentrationthe filtrate is concentrated to dryness by evaporation
  3. customrecrystallised from methanol

Sources & evidence

ORD record
ord-3f30685922ef4e2d8de5502888a865c6
Source dataset
uspto-grants-1984_05
Patent number
US04451462

Reaction notes

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