Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 7-[3-[4-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro--1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| 반응물 | 1,1-Dimethylethyl[[4-(3-pyrrolidinyl)phenyl]methyl]carbamate | HCID 86746986 | — |
| 생성물 | 7-[3-[4-(Aminomethyl)phenyl]-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro--1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 15288430 | — |
반응 단계
Starting from 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.88 g, 3.3 mmol) and 1,1-dimethylethyl[[4-(3-pyrrolidinyl)-phenyl]methyl]carbamate, a procedure analogous to that given in Example 6 provided the title compound (1.02 g) as a bright yellow solid, mp 268°-272° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622966 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-ee8762884d1541a99aa2de0ba050836d |
| 출처 메모 | uspto-grants-1997_04 |