HRID544781

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13408

1,2-Dimethylindole

C10H11N

HCID19796639

未命名化合物

结构：CCc1[nH]c2ccc(C)cc2c1C(=O)C(Cl)=C(Cl)C(=O)O

HCID53738561

未命名化合物

PRODUCTS

生成物

结构：CCc1[nH]c2ccc(C)cc2c1C1(c2cn(Cc3ccccc3)c3ccc(F)cc23)OC(=O)C(Cl)=C1Cl

HCID20442719

未命名化合物

PROCEDURE

实验过程

Following a procedure similar to that described above in part B of this example except that 4-(2-ethyl-5-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid is used in place of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-benzyl-5-fluoroindole is substituted for 1,2-dimethylindole, there is obtained 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone (Formula V: R=R3 =H; R1 =CH3CH2 ; R2 =C6H5CH2 ; Y=5-CH3 ; Y1 =5-F).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ed37660a3ff4a87a984e6813d11c208
来源数据集: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04451657
来源说明: uspto-grants-1984_05

反应 SMILES

[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](=O)[C:13]([Cl:19])=[C:14]([Cl:18])[C:15]([OH:17])=[O:16])=[CH:9][C:8]([CH3:21])=[CH:7][CH:6]=2)[CH3:2].[CH2:22]([N:29]1[C:37]2[C:32](=[CH:33][C:34]([F:38])=[CH:35][CH:36]=2)[CH:31]=[CH:30]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.CN1C2C(=CC=CC=2)C=C1C>>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]1([C:31]3[C:32]4[C:37](=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=4)[N:29]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:30]=3)[O:16][C:15](=[O:17])[C:14]([Cl:18])=[C:13]1[Cl:19])=[CH:9][C:8]([CH3:21])=[CH:7][CH:6]=2)[CH3:2]