HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-fluoro-1-(beta-D-glucopyranosyl)indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal | HCID 107526 | — |
| Reactant | 4-Fluoro-2,3-dihydro-1H-indole | HCID 16244440 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-fluoro-1-(beta-D-glucopyranosyl)indoline | HCID 67020383 | — |
Reaction Steps
A mixture of 4-fluoroindoline (185 mg) and D-glucose (267 mg) in H2O (0.74 ml)-ethyl alcohol (9 ml) was refluxed under argon atmosphere for 24 hours. The solvent was evaporated under reduced pressure to give crude 4-fluoro-1-(β-D-glucopyranosyl)indoline, which was used in the subsequent step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935674B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-7f8f05e9c5d24bcca0928593014d821c |
| Source note | uspto-grants-2011_05 |