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5-Bromothiophene-2-carbonyl chloride → 5-bromo-2-thienyl 4-methyl-1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromothiophene-2-carbonyl chloride | HCID 605712 | — |
| 反応物 | 4-methyl-1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indole | HCID 67195878 | — |
| 生成物 | 5-bromo-2-thienyl 4-methyl-1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl ketone | HCID 67199034 | — |
反応手順
4-Methyl-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-indole obtained in Example 23-(1) and 5-bromothiophene-2-carbonyl chloride were treated in a manner similar to Example 21-(1) to give 5-bromo-2-thienyl 4-methyl-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)indol-3-yl ketone as a yellow powder. APCI-Mass m/Z 650/652 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935674B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-27c81cb2c2714add894e9426b9ee003f |
| 出典メモ | uspto-grants-2011_05 |