HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloroindoline → 4-Chloro-5-fluoroindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloroindoline | HCID 16244448 | — |
| Reactant | ethyl 4-chloro-5-fluoro-1H-indole-2-carboxylate | HCID 18986263 | — |
| Product | 4-Chloro-5-fluoroindoline | HCID 44182339 | — |
Reaction Steps
The above ethyl 4-chloro-5-fluoroindole-2-carboxylate was treated in a manner similar to Reference Example 10-(3), (4) and 1 to give the titled compound, 4-chloro-5-fluoroindoline as a brown oil. APCI-Mass m/Z 172/174 (M+H). 1H-NMR (DMSO-d6) δ 2.97 (t, J=8.7 Hz, 2H), 3.48 (td, J=8.7, 1.9 Hz, 2H), 5.67 (s, 1H), 6.37 (dd, J=8.5, 3.7 Hz, 1H), 6.90 (t, J=9.2 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935674B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-2b3a6d59dde54cb28a588000d983b020 |
| Source note | uspto-grants-2011_05 |