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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 544926Generated: October 25, 2026

5-Bromothiophene-2-carboxylic acid → 5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

https://huagongshe.com/reaction/544926

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromothiophene-2-carboxylic acidHCID 349115—
Reactant3-Amino-N-cyclopropyl-4-methylbenzamide hydrochlorideHCID 44203194—
Product5-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamideHCID 59761401—

Reaction Steps

Compound a was prepared by coupling 5-bromothiophene-2-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO04071440) using the method described in Example 2. HPLC Ret time=3.16 min. LCMS [M+H]+ 379.15.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07935696B2
Source datasetuspto-grants-2011_05
ORD IDord-138e84d3320144aabfa24313e65fcc77
Source noteuspto-grants-2011_05