Methyl 3-amino-4-methylbenzoate → HCID 16387575, compound

HRID 544928Notes

Reaction equation

HRID 544928 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([CH:18]=[CH:19][C:20]=1[CH3:21])[C:14]([O:16][CH3:17])=[O:15]>>[Br:1][C:2]1[S:6][C:5]([C:7]([NH:10][C:11]2[CH:12]=[C:13]([CH:18]=[CH:19][C:20]=2[CH3:21])[C:14]([O:16][CH3:17])=[O:15])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 337778Methyl 3-amino-4-methylbenzoateHCID 3491155-Bromothiophene-2-carboxylic acid

Product 1

HCID 16387575HCID 16387575, compoundYield 88%

Procedure

Compound a was prepared by coupling 5-bromothiophene-2-carboxylic acid with commercially available methyl 3-amino-4-methylbenzoate using the method described in Example 128 to afford a white solid in 88% yield. HPLC Ret time=3.25 min. LCMS [M+H]+ 355.2.

Workup

  1. customCompound a was prepared
  2. customto afford a white solid in 88% yield
  3. customHPLC Ret time=3.25 min

Sources & evidence

ORD record
ord-4ebcae97db134f369c68a48de449ca18
Source dataset
uspto-grants-2011_05
Patent number
US07935696B2

Reaction notes

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