m-Chloroperbenzoic acid → HCID 24985751, compound

Participants

Reaction Steps

To a slurry of N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-5-(pyridin-3-yl)thiophene-2-carboxamide (Example 149, 30 mg, 0.079 mmol) in CH2Cl2 (0.5 mL) at rt was added m-CPBA (19 mg, 0.083 mmol) and the resulting slurry was stirred at rt for 30 min then at 35° C. for 4.5 h. The mixture was concentrated under vacuum and the resulting solid was slurried in MeOH (˜2 mL) and the solid was collected by vacuum filtration and rinsed with add'n MeOH (˜1 mL). The resulting solid was dried in the funnel then under vacuum overnight to afford 25 mg (80%) of an off-white solid as the title compound (Example 196). HPLC Ret. Time=2.34 min, LCMS [M+H]+ 394.10.

Provenance & Evidence