4-Bromo-3-methylthiophenecarboxylic acid → 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide

HRID 544932Notes

Reaction equation

HRID 544932 reaction equation
[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([C:7]([OH:9])=O)[S:5][CH:6]=1.Cl.[NH2:12][C:13]1[CH:14]=[C:15]([CH:22]=[CH:23][C:24]=1[CH3:25])[C:16]([NH:18][CH:19]1[CH2:21][CH2:20]1)=[O:17]>>[Br:1][C:2]1[C:3]([CH3:10])=[C:4]([C:7]([NH:12][C:13]2[CH:14]=[C:15]([C:16](=[O:17])[NH:18][CH:19]3[CH2:21][CH2:20]3)[CH:22]=[CH:23][C:24]=2[CH3:25])=[O:9])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 27570734-Bromo-3-methylthiophenecarboxylic acidHCID 442031943-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride

Product 1

HCID 597615124-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide

Procedure

The compound a was prepared by coupling commercially available 4-bromo-3-methylthiophene-2-carboxylic acid with 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO 04/071440) using the method described in Example 128. HPLC Ret time=3.12 min. LCMS [M+H]+ 393.13.

Workup

  1. customThe compound a was prepared
  2. customHPLC Ret time=3.12 min

Sources & evidence

ORD record
ord-8c7a69286ac44b2595ada6fa03a3c462
Source dataset
uspto-grants-2011_05
Patent number
US07935696B2

Reaction notes

Loading…