HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(5-fluoropyridin-3-yl)-3-methylthiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 16414268 | — |
| Reactant | 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide | HCID 59761512 | — |
| Product | N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(5-fluoropyridin-3-yl)-3-methylthiophene-2-carboxamide | HCID 24985755 | — |
Reaction Steps
The title compound was prepared by coupling 4-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-3-methylthiophene-2-carboxamide with commercially available 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine using the method described in Step B of Example 136 to afford a white solid (Example 200). HPLC Ret time=2.98 min. LCMS [M+H]+ 410.22.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935696B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-59b56f6c2d4f4e8dad3096599bbcc903 |
| Source note | uspto-grants-2011_05 |