HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide → N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(pyridin-3-yl)thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide | HCID 59761499 | — |
| Reactant | 3-Pyridylphenylboronic acid | HCID 66725065 | — |
| Product | N-(5-(Cyclopropylcarbamoyl)-2-methylphenyl)-4-(pyridin-3-yl)thiophene-2-carboxamide | HCID 24985914 | — |
Reaction Steps
The title compound was prepared by coupling 4-bromo-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide with commercially available 3-pyridylphenylboronic acid using the method described in Step B of Example 136 to afford a white solid (Example 204). HPLC Ret time=1.91 min. LCMS [M+H]+ 378.22.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935696B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-368444f696af408da59c7307809044d7 |
| Source note | uspto-grants-2011_05 |