7-fluoro-2,3,4,5-tetrahydro-1H-1-benzazepine-2,5-dione → 4-Dimethylaminomethylene-8-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

HRID 544987Notes

Reaction equation

HRID 544987 reaction equation
[CH3:1][N:2]([CH3:19])[CH:3]1C(=C)C(=O)NC2C=CC(OC)=CC=2C1=O.FC1C=CC2NC(=O)CCC(=O)C=2C=1.[CH3:34][C:35]1[CH:36]=[CH:37][C:38]2[C:44](=[O:45])[CH2:43][CH2:42][C:41](=[O:46])[NH:40][C:39]=2[CH:47]=1>>[CH3:1][N:2]([CH:19]=[C:43]1[CH2:42][C:41](=[O:46])[NH:40][C:39]2[CH:47]=[C:35]([CH3:34])[CH:36]=[CH:37][C:38]=2[C:44]1=[O:45])[CH3:3]

Participants

4

Reactant 3

HCID 234409367-fluoro-2,3,4,5-tetrahydro-1H-1-benzazepine-2,5-dioneHCID 584766398-methyl-3,4-dihydro-1H-1-benzazepine-2,5-dioneHCID 669347774-dimethylamino-methylene-7-methoxy-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Product 1

HCID 669345664-Dimethylaminomethylene-8-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

Procedure

In a manner similar to that described above for 4-dimethylamino-methylene-7-methoxy-3,4-dihydro-1H-benzo[b]azepine-2,5-dione, 7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione, 0.64 g of 8-methyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione was converted to v-g (87%): MS m/z=245 (M+H).

Sources & evidence

ORD record
ord-a1fe80c48fec4d4fa2fa0d95854eec47
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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