HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 9-Chloro-2-(3,4-dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Reactant | N-(3,4-dimethoxyphenyl)guanidine | HCID 178492306 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 9-Chloro-2-(3,4-dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 11502143 | — |
Reaction Steps
In a manner similar to method I (DMF and NaHCO3 were used in place of EtOH and K2CO3), 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]-azepine-2,5-dione (v-j) and 1-(3,4-dimethoxyphenyl)guanidine were converted to I-2 (87%): HRMS Calcd. for C20H17ClN4O3: 397.1067, Found 397.109.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-607c04d0e6084e69b375fedab476d49d |
| Source note | uspto-grants-2011_05 |