反应详情

温度

110 °C

2-Amino-10-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-51) (69.7 mg, 0.20 mmol) was dissolved in pyridine (800 μL) and benzoyl chloride (23 mL, 0.20 mmol). The mixture was stirred at 110° C. for 1 h, then cooled to 22° C. Et2O was added and the product was filtered from the solution to give I-83 (37%): MS (FA) Rt=1.49 min, m/z=457 (M+H).

1. temperaturecooled to 22° C
2. filtrationthe product was filtered from the solution
3. customto give I-83 (37%)