tert-Butyl (3-aminopropyl)carbamate → HCID 59852094, compound

Participants

Reaction Steps

In a manner similar to that described in Method N, 2-(3,4-dimethoxy-phenylamino)-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepine-10-carboxylic acid (I-43) and 3-amino-propyl-carbamic acid tert-butyl ester were converted to (3-{[2-(3,4-dimethoxy-phenylamino)-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepine-10-carbonyl]-amino}-propyl)-carbamic acid tert-butyl ester, which was subsequently deprotected (Method K) and purified by C-18 RP LC-MS chromatography to give I-76 (14%): HRMS Calcd. for C24H26N6O4: 463.2093, Found 463.2085.

Provenance & Evidence