4-Pyridineethanamine → HCID 59851208, compound

HRID 545009Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:13]=[CH:14][C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[CH:24][C:25]([C:27](O)=[O:28])=[CH:26][C:17]=4[C:16]=3[N:30]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[N:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH2:38][NH2:39])=[CH:33][CH:32]=1>>[N:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH2:38][NH:39][C:27]([C:25]2[CH:24]=[CH:23][C:18]3[NH:19][C:20](=[O:22])[CH2:21][C:15]4[CH:14]=[N:13][C:12]([NH:11][C:5]5[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=5)=[N:30][C:16]=4[C:17]=3[CH:26]=2)=[O:28])=[CH:33][CH:32]=1

Participants

Reactant 2

HCID 832754-Pyridineethanamine

HCID 59852114HCID 59852114, compound

Product 1

HCID 59851208HCID 59851208, compound

Procedure

In a manner similar to that described for Method N, 2-(3,4-dimethoxy-phenylamino)-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepine-10-carboxylic acid (I-43) and 2-(pyridin-4-yl)ethanamine were converted I-48 (6%): HRMS Calcd. for C28H26N6O4: 551.2093, Found 511.2098.

Sources & evidence

ORD record: ord-12cca6a6219b4efc93c53794bbfb4639
Source dataset: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07935694B2

Reaction notes

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