HCID 66934668, compound → 4-(10-Bromo-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-benzoic acid

HRID 545010Notes

Reaction equation

HRID 545010 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7](=[O:16])[CH2:8][C:9](=[CH:12]N(C)C)[C:10](=O)[C:4]=2[CH:3]=1.[NH:19]([C:23]1[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=1)[C:20]([NH2:22])=[NH:21]>>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7](=[O:16])[CH2:8][C:9]3[CH:12]=[N:22][C:20]([NH:19][C:23]4[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=4)=[N:21][C:10]=3[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 66934668HCID 66934668, compoundHCID 178512548HCID 178512548, compound

Product 1

HCID 598518434-(10-Bromo-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-benzoic acid

Procedure

In a manner similar to method I, 7-bromo-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-k) and 4-guanidinobenzoic acid were converted to I-25 (22%): HRMS Calcd. for C19H13BrN4O3: 425.0249, Found 425.0269.

Sources & evidence

ORD record
ord-73ac6c5fb1fb4bab81dc46979bf143e7
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

Loading…