HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 9-Chloro-2-(3-hydroxymethyl-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]-azepine-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Reactant | N-[3-(Hydroxymethyl)phenyl]guanidine | HCID 178512491 | — |
| Product | 9-Chloro-2-(3-hydroxymethyl-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]-azepine-6-one | HCID 59851100 | — |
Reaction Steps
In a manner similar to method I, 8-chloro-4-((dimethylamino)methylene)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 1-(3-(hydroxymethyl)phenyl)-guanidine were converted to I-79 (51%): HRMS Calcd. for C19H15ClN4O2: 367.0961, Found 367.0973.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-ff53d2ee4c334b1b8ed984256b47276f |
| Source note | uspto-grants-2011_05 |