HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 9-Chloro-2-(2-chloro-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Reactant | Chlorophenylguanidine | HCID 178512473 | — |
| Product | 9-Chloro-2-(2-chloro-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851239 | — |
Reaction Steps
In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 1-(2-chlorophenyl)guanidine were converted to I-12 (26%): HRMS Calcd. for C, H12Cl2N4O: 371.0466, Found 371.0467.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-70e0d83f6c5340d8878f2ddd794176ba |
| Source note | uspto-grants-2011_05 |