HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 9-Chloro-2-(2-methoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Reactant | N-(2-Methoxy-phenyl)-guanidine | HCID 178489590 | — |
| Product | 9-Chloro-2-(2-methoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59852027 | — |
Reaction Steps
In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 1-(2-methoxyphenyl)guanidine were converted to I-16 (39%): HRMS Calcd. for C11H11ClN4O2: 367.0961, Found 367.0947.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-3f5b0d13820949518beeacc52e190094 |
| Source note | uspto-grants-2011_05 |