HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 10-Chloro-2-(3,4-dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934727 | — |
| Reactant | HCID 178492307 | HCID 178492307 | — |
| Product | 10-Chloro-2-(3,4-dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851355 | — |
Reaction Steps
In a manner similar to that described for method I, 7-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-d) and N-(3,4-dimethoxyphenyl)guanidine nitrate were converted to I-24 (67%): HRMS Calcd. for C20H17ClN4O3: 397.1067, Found 397.1059.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-c00fc6d0c1284fa280c0c4a4196de45d |
| Source note | uspto-grants-2011_05 |