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tert-butyl N-(prop-2-yn-1-yl)carbamate → HCID 59851457、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl N-(prop-2-yn-1-yl)carbamate | HCID 11073648 | — |
| 反応物 | 9-Chloro-2-(3-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851283 | — |
| 反応物 | {3-[3-(9-chloro-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester | HCID 66934682 | — |
| 生成物 | HCID 59851457 | HCID 59851457 | — |
反応手順
In a manner similar to that described for Method O, 9-chloro-2-(3-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-58) and tert-butyl prop-2-ynylcarbamate was converted to {3-[3-(9-chloro-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)-phenyl]-prop-2-ynyl}-carbamic acid tert-butyl ester, which was subsequently deprotected according to Method Kto give I-67 (62%): HRMS Calcd. for C21H16ClN5O: 390.1121, Found 390.1117.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935694B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-e1e382f1f31344a08be3df4342388e6a |
| 出典メモ | uspto-grants-2011_05 |