HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Prop-2-yn-1-yl)pyrrolidine → 9-Chloro-2-[3-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5H,7H-benzo[b]-pyrimido[4,5-d]azepin-6one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Prop-2-yn-1-yl)pyrrolidine | HCID 299616 | — |
| Reactant | 9-Chloro-2-(3-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851283 | — |
| Product | 9-Chloro-2-[3-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5H,7H-benzo[b]-pyrimido[4,5-d]azepin-6one | HCID 59851631 | — |
Reaction Steps
In a manner similar to that described for Method O, 9-chloro-2-(3-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (v-j) and 1-(prop-2-ynyl)pyrrolidine were converted to I-89 (46%): MS (AA) Rt=1.32 min, m/z=444 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07935694B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-ca06cbc7071249f489ec0ee03c5199ef |
| Source note | uspto-grants-2011_05 |