1-(Prop-2-yn-1-yl)pyrrolidine → HCID 59851376, compound

HRID 545047Notes

Reaction equation

HRID 545047 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:13]=[CH:14][C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24](I)[CH:25]=[CH:26][C:17]=4[C:16]=3[N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:29]([N:32]1[CH2:36][CH2:35][CH2:34][CH2:33]1)[C:30]#[CH:31]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:13]=[CH:14][C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24]([C:31]#[C:30][CH2:29][N:32]5[CH2:36][CH2:35][CH2:34][CH2:33]5)[CH:25]=[CH:26][C:17]=4[C:16]=3[N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 2996161-(Prop-2-yn-1-yl)pyrrolidineHCID 56946380HCID 56946380, compound

Product 1

HCID 59851376HCID 59851376, compound

Procedure

In a manner similar to that described above for Method O, 2-(3,4-dimethoxy-phenylamino)-9-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-30) and 1-(prop-2-ynyl)pyrrolidine were converted to I-32 (42%): HRMS Calcd. for C27H27N5O3: 470.2192, Found 470.2192.

Sources & evidence

ORD record
ord-8e5916d7de784c3580826d326212eea6
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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