Propargyl alcohol → HCID 59851607, compound

HRID 545051Notes

Reaction equation

HRID 545051 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:13]=[CH:14][C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24](I)[CH:25]=[CH:26][C:17]=4[C:16]=3[N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:29]([OH:32])[C:30]#[CH:31]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][C:12]2[N:13]=[CH:14][C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24]([C:31]#[C:30][CH2:29][OH:32])[CH:25]=[CH:26][C:17]=4[C:16]=3[N:28]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 7859Propargyl alcoholHCID 569463802-(3,4-dimethoxy-phenylamino)-9-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one

Product 1

HCID 59851607HCID 59851607, compound

Procedure

In a manner similar to that described for Method O, 2-(3,4-dimethoxy-phenylamino)-9-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-30) and prop-2-yn-1-ol were converted to I-52 (38%): HRMS Calcd. for C23H20N4O4: 417.1562, Found 417.1551.

Sources & evidence

ORD record
ord-e307e9e7a6c8467fa53f2e907dc91e84
Source dataset
uspto-grants-2011_05
Patent number
US07935694B2

Reaction notes

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