Water → (3-Amino-phenyl)-acetonitrile

HRID 545061노트

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HRID 545061 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O.O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][C:11]#[N:12])[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 962WaterHCID 121253-Nitrophenylacetonitrile

생성물 1

HCID 4847850(3-Amino-phenyl)-acetonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

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온도
22 °C

실험 절차

To a solution of 3-nitro-phenyl-acetonitrile (3.20 g, 19.7 mmol) in MeOH (50 mL) was added Pd/C (10% wt, ˜50% H2O, 0.32 g) and the mixture was placed under H2 (80 psi) and stirred for 2 days at 22° C. The reaction mixture was filtered through Celite® and the filtrate concentrated in vacuo to give crude product as a yellow oil. The residue was purified by silica gel chromatography (ISCO, elution with 0-10% ethyl acetate in hexanes) to give xix-l-1 (1.15 g, 44%): MS m/z=133 (M−H).

후처리

  1. filtrationThe reaction mixture was filtered through Celite®
  2. concentrationthe filtrate concentrated in vacuo
  3. customto give crude product as a yellow oil
  4. customThe residue was purified by silica gel chromatography (ISCO, elution with 0-10% ethyl acetate in hexanes)
  5. customto give xix-l-1 (1.15 g, 44%)

출처 및 근거

ORD 기록
ord-59dc976af85b44588328b643dce85dfe
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935694B2

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