Acetic Acid Mixture with Hydrobromic Acid → Hydrogen Bromide

Participants

Reaction Steps

Dissolve 7-[6-ethoxy-4-(trifluoromethyl)pyridazin-3-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]-1,8-naphthyridin-4-amine (560 mg, 1.16 mmol) in HBr/AcOH (33% wt; 10 mL) and stir for 4 hours at room temperature. Remove the solvent under reduced pressure. Add toluene (25 mL) and remove the solvent under reduced pressure. Dry under vacuum to yield the title compound as its HBr salt (618 mg, 100%). LC/MS (MH+) 453.97.

Provenance & Evidence