HRID545120

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID118642

4-Chloro-3-(trifluoromethyl)benzaldehyde

C8H4ClF3O

结构：CCOC(=O)Cc1csc(SCC(=O)NC[C@@H]2CNCCO2)n1

HCID67169399

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cc1csc(SCC(=O)NC[C@H]2CN(Cc3ccc(Cl)cc3)CCO2)n1

HCID67168675

未命名化合物

结构：CCOC(=O)Cc1csc(SCC(=O)NC[C@H]2CN(Cc3ccc(Cl)c(C(F)(F)F)c3)CCO2)n1

HCID67168871

未命名化合物

PROCEDURE

实验过程

By a similar method as in (85-1), the title compound (663 mg) was obtained as a colorless oil from the resultant product (899 mg) of (75-3) and 4-chloro-3-trifluoromethylbenzaldehyde (396 μL).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-27bf704376c34903820ed2eb95adfcb7
来源数据集: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07935700B2
来源说明: uspto-grants-2011_05

反应 SMILES

[CH2:1]([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([S:12][CH2:13][C:14]([NH:16][CH2:17][C@H:18]2[O:23][CH2:22][CH2:21][NH:20][CH2:19]2)=[O:15])[S:10][CH:11]=1)=[O:5])[CH3:2].[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][C:26]=1[C:33]([F:36])([F:35])[F:34]>>[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][N:20]2[CH2:21][CH2:22][O:23][C@@H:18]([CH2:17][NH:16][C:14](=[O:15])[CH2:13][S:12][C:9]3[S:10][CH:11]=[C:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[N:8]=3)[CH2:19]2)=[CH:27][CH:26]=1.[Cl:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][N:20]2[CH2:21][CH2:22][O:23][C@@H:18]([CH2:17][NH:16][C:14](=[O:15])[CH2:13][S:12][C:9]3[S:10][CH:11]=[C:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[N:8]=3)[CH2:19]2)=[CH:27][C:26]=1[C:33]([F:34])([F:35])[F:36]