反应详情

2-(4-Bromophenoxy)-2-methylpropionic acid (1 g) was dissolved in methanol (5 mL), a catalytic amount of thionyl chloride was added, and the mixture was stirred at room temperature for 7 hrs. Saturated brine was added to the reaction mixture, and the mixture was extracted with a mixed solvent of chloroform-methanol. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (920 mg) as a colorless oil.

1. extractionthe mixture was extracted with a mixed solvent of chloroform-methanol
2. dry with materialThe extract was dried over anhydrous sodium sulfate
3. customthe solvent was evaporated under reduced pressure