HCID 57440888, compound → HCID 135441354, compound

HRID 545184Notes

Reaction equation

HRID 545184 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[C:10]([O:15][CH3:16])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([C:17]([OH:19])=O)[CH:6]=1.[O:20]=[C:21]1[C:35]2[C:30](=[CH:31][CH:32]=[C:33]([C:36]3[NH:37][O:38][C:39](=[O:41])[N:40]=3)[CH:34]=2)[O:29][C:23]2([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH2:22]1>>[OH:1][CH2:2][CH2:3][O:4][C:5]1[C:14]2[C:9](=[C:10]([O:15][CH3:16])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([C:17]([N:26]2[CH2:27][CH2:28][C:23]3([CH2:22][C:21](=[O:20])[C:35]4[C:30](=[CH:31][CH:32]=[C:33]([C:36]5[NH:40][C:39](=[O:41])[O:38][N:37]=5)[CH:34]=4)[O:29]3)[CH2:24][CH2:25]2)=[O:19])[CH:6]=1

Participants

3

Reactant 2

HCID 57440888HCID 57440888, compoundHCID 178515375HCID 178515375, compound

Product 1

HCID 135441354HCID 135441354, compound

Procedure

The compound was prepared according to the procedure described in the Example 1, using 4-(2-hydroxyethoxy)-8-methoxy-2-naphthoic acid instead of 4,8-dimethoxyquinoline-2-carboxylic acid, and 3-[4-oxospiro(chroman-2,4′-piperidin)-6-yl]-5-oxo-1,2,4-oxadiazole instead of 4-oxospiro(chroman-2,4′-piperidin)-6-yl acetamide. 1H-NMR (400 MHz, DMSO-d6) δ; 8.24 (1H, d, J=4.0 Hz), 8.04 (1H, dd, J=4.0, 8.0 Hz), 7.86 (1H, d, J=8.0 Hz), 7.75 (1H, s), 7.51 (1H, t, J=8.0 Hz), 7.34 (1H, d, J=8 Hz), 7.09 (1H, d, J=8 Hz), 7.00 (1H, s), 4.40-4.22 (1H, m), 4.20 (2H, t, J=4.0 Hz), 4.01 (3H, s), 3.92-3.89 (2H, m), 3.75-3.30 (3H; m), 3.03 (2H, s), 2.12-1.75 (4H, m). MS [M+H]+=546.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-903d0e71895a4ffda24bf6a4baa19aab
Source dataset
uspto-grants-2011_05
Patent number
US07935712B2

Reaction notes

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