HCID 178451554, compound → HCID 178515376, compound

HRID 545200Notes

Reaction equation

HRID 545200 reaction equation
[O:1]=[C:2]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:24]3[NH:28][N:27]=[N:26][N:25]=3)[CH:22]=2)[O:17][C:4]2([CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]2)[CH2:3]1>Cl.O1CCOCC1>[NH:28]1[C:24]([C:21]2[CH:22]=[C:23]3[C:18](=[CH:19][CH:20]=2)[O:17][C:4]2([CH2:9][CH2:8][NH:7][CH2:6][CH2:5]2)[CH2:3][C:2]3=[O:1])=[N:25][N:26]=[N:27]1

Participants

3

Reactant 1

HCID 178451554HCID 178451554, compound

Product 1

HCID 178515376HCID 178515376, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4 N HCl-1,4-dioxane (200 mL) was added to 40.6 g tert-butyl 4-oxo-6-(1H-tetrazol-5-yl)spiro[chroman-2,4′-piperidine]-1′-carboxylate produced in Reference Example 6, and stirred at room temperature for 5 hours. The reaction mixture was concentrated, and the residue was triturated with methanol. The insoluble solid was collected through filtration, and dried under reduced pressure to obtain 6-(1H-tetrazol-5-yl)-spiro[chroman-2,4′-piperidine]-4-one as a colorless solid.

Workup

  1. customproduced in Reference Example 6
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was triturated with methanol
  4. filtrationThe insoluble solid was collected through filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-6eb9e0e833534cbab7716851146d57ab
Source dataset
uspto-grants-2011_05
Patent number
US07935712B2

Reaction notes

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