Tetrahydrofuran → 8-Cyclopropyl-4-methoxyquinoline-2-carboxylic acid

Participants

Reaction Steps

30.0 g of methyl 8-cyclopropyl-4-methoxyquinoline-2-carboxylate, 250 ml of THF and 400 ml of MeOH was placed in 2 L-flask, and 46 ml of 5N NaOH aq. was added, and stirred for 1 h. The mixture was concentrated in vacuo and diluted with water. 46 ml of 5N HCl aq. was added with cooling in ice bath, extracted with 500 ml of CHCl3-MeOH (4-1), dried over Na2SO4 and filtered. The filtrate was concentrated to afford a yellow solid. The solid was washed with hexane-CHCl3, filtered and dried under vacuum to afford 8-cyclopropyl-4-methoxyquinoline-2-carboxylic acid.

Provenance & Evidence