反应详情

With cooling with ice, 426 mg of sodium borohydride was added to ethanol (50 mL) solution of 4.50 g of 2-acetyl-6-bromopyridine. After stirred for 1 hour, aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, 4.58 g of the entitled compound was obtained as a colorless oily substance.

1. extractionextracted with ethyl acetate
2. washwashed with saturated saline water
3. dry with materialdried with anhydrous magnesium sulfate
4. concentrationAfter concentrated under reduced pressure