HCID 43461608, compound → HCID 86616125, compound

HRID 545263Notes

Reaction equation

HRID 545263 reaction equation
[CH2:1]([N:4]1[C:12](=[O:13])[C:11]2[C:6](=[N:7][C:8](SC)=[N:9][CH:10]=2)[N:5]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=1)[CH:2]=[CH2:3].[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][N:33]([CH2:36][C:37]([N:39]([CH3:41])[CH3:40])=[O:38])[CH2:32][CH2:31]2)=[CH:26][CH:25]=1>>[CH3:40][N:39]([CH3:41])[C:37](=[O:38])[CH2:36][N:33]1[CH2:32][CH2:31][N:30]([C:27]2[CH:28]=[CH:29][C:24]([NH:23][C:8]3[N:7]=[C:6]4[N:5]([C:16]5[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[N:17]=5)[N:4]([CH2:1][C:2]#[CH:3])[C:12](=[O:13])[C:11]4=[CH:10][N:9]=3)=[CH:25][CH:26]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 43461608HCID 43461608, compoundHCID 67170500HCID 67170500, compound

Product 1

HCID 86616125HCID 86616125, compound

Procedure

34.3 mg of the entitled compound was obtained as a yellow solid in the same manner as in Example 113-1 to 113-2, for which, however, 2-allyl-1-(6-methylpyridin-2-yl)-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one was used in place of 2-allyl-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one used in Example 113-1, and 2-[4-(4-aminophenyl)piperazin-1-yl]-N,N-dimethylacetamide was used in place of 4-(4-methylpiperazin-1-yl) aniline used in Example 113-2.

Sources & evidence

ORD record
ord-4f17ca817ff34e539ef4a8bedff2f937
Source dataset
uspto-grants-2011_05
Patent number
US07935708B2

Reaction notes

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