化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-(2-methoxyphenyl)-1-methyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 2-Methoxyphenylboronic acid | HCID 2733958 | — |
| 反応物 | 1-Methyl-6-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-3-ol | HCID 21098027 | — |
| 触媒 | Cupric acetate | HCID 8895 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 溶媒 | chloroform N,N-dimethylformamide | HCID 21754633 | — |
| 生成物 | 2-(2-methoxyphenyl)-1-methyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | HCID 67171354 | 49% |
反応手順
280 mg of o-methoxyphenylboronic acid, 320 mg of copper(II) acetate and 0.15 mL of pyridine were added to a chloroform/N,N-dimethylformamide (1/1) solution of 90 mg of 1-methyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, and stirred at room temperature. Aqueous 28% ammonia solution and saturated sodium hydrogencarbonate solution were added to the reaction liquid, and extracted with chloroform. The crude product was purified through a silica gel column (hexane/ethyl acetate) to obtain 68 mg of 2-(2-methoxyphenyl)-1-methyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07935708B2 |
| 出典データセット | uspto-grants-2011_05 |
| ORD ID | ord-423e0abbca5b4a1495b5da35ebeaece3 |
| 出典メモ | uspto-grants-2011_05 |