Bromobenzene → HCID 57619637, compound

Participants

Reaction Steps

257 mg of ethyl 1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxyl ate and 260 mg of 2-aminoimidazole were added to 5 ml of bromobenzene, then, the mixture was stirred for 2 hours under heat refluxing condition. Further, to the mixture was added 151 mg of ethyl 1,6-dimethyl-4-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxyl ate, and the resultant mixture was stirred for 2.5 hours under heat refluxing condition. The reaction mixture was cooled to room temperature. The resulting solid was collected by filtration, and washed with a mixed solvent of t-butyl methyl ether and hexane and dried to obtain 580 mg of 1,6-dimethyl-4-hydroxy-N-(2-imidazolyl)-2-oxo-1,2-dihydropy ridine-3-carboxamide (hereinafter, referred to as present compound 26) represented by the formula:

Provenance & Evidence